The Uprising is a resistance group first seen in the episode "The Closer You Get".
It is unknown when and by how the Uprising was formed. Early in the episode, Tribore mentions he was holed up in an abandoned Uprising transmitting tower when he received a message from Quinn Ergon. Later, while the Crimson Light is at Kanopus Prime, the Uprising fleet confronts them since the planet is part of Uprising Space. Their leader is revealed to be Shannon Thunder, a former member of Tribore's first resistance. She is delighted to see Tribore again, and claims the Uprising could really use help from his newly reformed Resistance, but Tribore claims to be too busy.
Shannon tells Tribore that the Uprising is "rebelling against the Insurgency". Any other purposes for the group's existance are unknown.